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Centre for Metabolic Diseases

       

 

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Climb Research Grants

 

 

 

 

Funded Projects 1982-2008

(click here)

 

 

Disclaimer

 

 

 

 

When Climb was founded way back in 1981 (as the Research Trust for Metabolic Diseases in Children), research was a key objective for the charity and it remains so today.  Since then we have funded research into over sixty different metabolic diseases through over 130 different research projects and to a value of more than £755,900.  This is an achievement of which Climb is rightly very proud.

The first project grant from Climb was made in 1982 with a value of £1,000 for an enzyme transfer project.  More recent projects have included research into OTC (£12,000), Mitochondrial disease (£10,261), Metabolic Liver Disease (£20,000) and Niemann Pick Type C disease (£8,000).

The outcomes of Climb funded research projects have been numerous and far reaching and include the development of a new treatment for Glycolipid Storage Diseases, new patient monitoring systems for CAH and Tyrosinaemia sufferers, the development of improved treatment regimes for Cystinosis and PKU and a closer understanding of the biochemistry of Lactic Acidosis, Malonyl-CoA Decarboxylase Deficiency and Urea Cycle Disorders.  Climb has funded projects ranging from those that have developed the basic understanding of cell biochemistry to those that have developed and evaluated new and better clinical treatments.

All potential projects are assessed by a peer review process before being selected on merit by Climb’s research sub-committee.  Projects approved for Grant by the Research Committee are referred to a full Board meeting at which Directors agree the funding of projects based upon the recommendations of the Research Sub-committee and available funding.  For more information on applying for a Research Grant from Climb, please click here.

 2000 – 2001 Funded research projects:

Dr Green

Birmingham Children’s

Hospital

Management of patients with Adrenoleukodystrophy

 

 

 

Dr Wraith

Willink Biochemical

Genetics Unit, Manchester

DNA Analysis

 

 

 

Dr Williams

Bath

Development of a Siblings Workbook

 

 

 

Dr Mehmet

Imperial College

London

The Molecular Basis of Apoptosis Induced by MSD Metabolites

 

 

 

 2001 – 2002 Funded research projects:

 

 

 

Dr Mehmet

Imperial College

London

The Molecular Basis of Apoptosis Induced by MSD Metabolites

 

 

 

 

 

 

2002 – 2003 Funded research projects:

 

 

 

Dr Mehmet

Imperial College

London

The Molecular Basis of Apoptosis Induced by MSD Metabolites

 

 

 

Dr Wallace

Glasgow

Testosterone Measurements to Assist Treatment Monitoring for CAH

 

 

 

2003 – 2004 Funded research projects:

 

 

 

Dr Mehmet

Imperial College, London

The Molecular Basis of Apoptosis Induced by MSD Metabolites

 

 

 

Dr Wallace

Glasgow

Testosterone Measurements to Assist Treatment Monitoring for CAH

 

 

 

Dr Rahman

Institute of Child Health

London

Analysis of Candidate Genes for Mitochondrial Respiratory Chain Disorders.

Dr Gissen

Birmingham Children’s

Hospital

Identification of Genes for Metabolic Disorders of the Liver

2004 - 2005 Funded research projects: 

Dr Paul Gissen

Birmingham Children’s

Hospital

Identification of Genes for Metabolic Disorders of the Liver

Professor Nils

Goran Larsson

Karolinska Institute

Sweden

Studies of mouse models of mitochondrial dysfunction to develop new diagnostic tools

2005-06 Funded research projects: 

Dr Stephen Rose

 

St James’ University Hospital

Leeds

Functional regulation of Niemann Pick Type C by ubiquitinylation

Professor Charles Coutelle

 

Imperial College

London

 

A preventative approach to OTC deficiency by in utero gene therapy in a mouse model

 2006-07 Funded research projects: 

Dr Paul Gissen

 

Birmingham Children’s Hospital

 

 

Molecular Pathology of ARC Syndrome

 

 

2007-2008 Funded research projects: 

 

Ms Dalvir Padda

Birmingham Childrens Hospital

Specialist Metabolic Nurse

 

2008-09 Funded research projects: 

 

Professor Timothy Cox

University of Cambridge

The Dr Hans and Mrs Gertrude Hirsch Tay Sachs Research Project

Dr Heidi Peters

Murdoch Childrens Research Institute

Royal Children's Hospital

Melbourne

Australia

Development of Pharmacological Therapies for treatment of the inborn error of organic acid metabolism Methylmalonic Aciduria
Dr Jan-Willem Taanman

University Department of Clinical Neurosciences, Institute of Neurology, UCL

Deoxyribonucleoside Triphosphate Supplementation of Succinate Coenzyme A Ligase-Deficient Patient Cells

Ms Dalvir Padda

Birmingham Childrens Hospital

Specialist Metabolic Nurse

In total, these projects represent expenditure of over £250,000 on research since 2000.  All this money has been raised through voluntary donations.