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When Climb was founded way
back in 1981 (as the Research Trust for Metabolic Diseases in Children), research was a
key objective for the charity and it remains so today. Since then we have
funded research into over sixty different metabolic diseases through over
130 different research projects and to a value of more than £755,900. This
is an achievement of which Climb is rightly very proud.
The first project grant from
Climb was made in 1982 with a value of £1,000 for an enzyme transfer
project. More recent projects have included research into OTC (£12,000),
Mitochondrial disease (£10,261), Metabolic Liver Disease (£20,000) and
Niemann Pick Type C disease (£8,000).
The outcomes of Climb
funded research projects have been numerous and far reaching and include the
development of a new treatment for Glycolipid Storage Diseases, new patient
monitoring systems for CAH and Tyrosinaemia sufferers, the development of
improved treatment regimes for Cystinosis and PKU and a closer understanding
of the biochemistry of Lactic Acidosis, Malonyl-CoA Decarboxylase Deficiency
and Urea Cycle Disorders. Climb has funded projects ranging from those that
have developed the basic understanding of cell biochemistry to those that
have developed and evaluated new and better clinical treatments.
All potential projects are
assessed by a peer review process before being selected on merit by Climb’s
research sub-committee. Projects approved for Grant by the Research Committee are
referred to a full Board meeting at which Directors agree the funding of
projects based upon the recommendations of the Research Sub-committee and
available funding. For more information on applying for a Research Grant
from Climb, please click
here.
2000
– 2001 Funded research projects:
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Dr
Green |
Birmingham Children’s
Hospital |
Management of patients with Adrenoleukodystrophy |
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Dr
Wraith |
Willink Biochemical
Genetics Unit, Manchester |
DNA
Analysis |
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Dr
Williams |
Bath |
Development of a Siblings Workbook |
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Dr
Mehmet |
Imperial College
London |
The
Molecular Basis of Apoptosis Induced by MSD Metabolites |
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2001 – 2002 Funded research projects: |
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Dr
Mehmet |
Imperial College
London |
The
Molecular Basis of Apoptosis Induced by MSD Metabolites |
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2002 – 2003 Funded research projects: |
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Dr
Mehmet |
Imperial College
London |
The
Molecular Basis of Apoptosis Induced by MSD Metabolites |
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Dr
Wallace |
Glasgow |
Testosterone Measurements to Assist Treatment Monitoring for CAH |
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2003 – 2004 Funded research projects: |
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Dr
Mehmet |
Imperial College, London |
The
Molecular Basis of Apoptosis Induced by MSD Metabolites |
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Dr
Wallace |
Glasgow |
Testosterone Measurements to Assist Treatment Monitoring for CAH |
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Dr
Rahman |
Institute of Child Health
London |
Analysis of Candidate Genes for Mitochondrial Respiratory Chain
Disorders. |
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Dr
Gissen |
Birmingham Children’s
Hospital |
Identification of Genes for Metabolic Disorders of the Liver |
2004 - 2005 Funded research projects:
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Dr
Paul Gissen |
Birmingham Children’s
Hospital |
Identification of Genes for Metabolic Disorders of the Liver |
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Professor Nils
Goran Larsson |
Karolinska Institute
Sweden |
Studies of mouse models of mitochondrial dysfunction
to develop new diagnostic tools |
2005-06
Funded research projects:
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Dr Stephen Rose
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St James’ University
Hospital
Leeds
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Functional
regulation of Niemann Pick Type C by ubiquitinylation |
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Professor Charles
Coutelle
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Imperial College
London
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A preventative
approach to OTC deficiency by in utero gene therapy in a mouse model |
2006-07
Funded research projects:
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Dr Paul Gissen
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Birmingham
Children’s Hospital
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Molecular Pathology
of ARC Syndrome
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2007-2008
Funded research projects:
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Ms Dalvir Padda |
Birmingham
Childrens Hospital |
Specialist
Metabolic Nurse |
2008-09
Funded research projects:
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Professor Timothy Cox |
University
of Cambridge |
The Dr Hans and Mrs Gertrude Hirsch Tay Sachs
Research Project |
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Dr Heidi
Peters |
Murdoch Childrens Research Institute
Royal Children's Hospital
Melbourne
Australia |
Development of
Pharmacological Therapies for treatment of the inborn error of organic
acid metabolism Methylmalonic Aciduria |
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Dr Jan-Willem Taanman |
University Department of Clinical Neurosciences, Institute of Neurology,
UCL |
Deoxyribonucleoside
Triphosphate Supplementation of Succinate Coenzyme A Ligase-Deficient
Patient Cells
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Ms Dalvir Padda |
Birmingham
Childrens Hospital |
Specialist Metabolic Nurse |
In
total, these projects represent expenditure of over £250,000 on research
since 2000. All this money has been raised through voluntary
donations.

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